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The Opioid Crisis is Growing Across North America

Governments across North America are taking urgent action to address the growing opioid crisis that is drastically gaining momentum. Current interventions have proven to be ineffective when trying to manage the growing overdose numbers and the number of patients experiencing debilitating withdrawal symptoms. We have compiled the latest articles on the subject, contextualizing the crisis, and emphasizing the global need for innovative Read more…

By AphioTx, ago

Researchers identify drug that alleviates opioid withdrawal

Opioid use and abuse is a significant social, health and economic issue in Canada. Researchers at the University of Calgary’s Faculty of Veterinary Medicine (UCVM) and Hotchkiss Brain Institute (HBI) at the Cumming School of Medicine (CSM) have discovered that an existing anti-gout medication is effective in reducing the severity of withdrawal symptoms in opioid-dependent rodents.

By AphioTx, ago

Inhibition of Pannexin-1 Channels on Microglia Reduces Morphine Withdrawal in Rodents

Opioids are the mainstay of treatment strategies to reduce pain, but withdrawal can be a serious problem when patients stop taking these drugs. However, beyond the recognition that microglia play a role in this phenomenon, little is known about the cellular mechanisms involved. Now, new research shows how microglia contribute to withdrawal in rodents and identifies a potential path toward easing withdrawal in patients.

By AphioTx, ago